PGS by CGH array: Prenatal Generic Screening

PGS by CGH array: Preimplantation Genetic Screening

PGS by array CGH or Prenatal Genetic Screening is a laboratory technique that allows us to study the DNA of eggs or embryos in order to select those with a correct genetic load.

This technique aims to select chromosomally normal embryos.
It is done as part of IVF programmes. Your doctor will tell you whether it could be helpful in your case.
CAN BE PERFORMED EITHER ON THE EGGS OR ON THE EMBRYOS, THE LATTER DELIVERING THE BEST RESULTS.
Chromosomal alterations affect either the number or the
structure of chromosomes. This technique allows their detection as well as the detection of other alterations, such as,  Turner and Down syndromes
Chromosomal alterations affect either the number or the structure of chromosomes. This technique allows their detection as well as the detection of other alterations, such as, Turner and Down syndromes.

Genetic study
After performing in vitro fertilization and before transfer to the uterus, the genetic material of the embryo is examined in order to detect likely genetic alterations.

It is performed when the embryos are at 6-8 cell stage, generally on the 3rd day of development, or when they are at the blastocyst stage, usually on day 5 of development.

Embryo biopsy
A biopsy is done on each one and those with an abnormal number of chromosomes are discarded.

Embryo transfer
From 1 to 3 healthy embryos are transferred.

The embryos that are not transferred can be frozen.

PGS by CGH array: Prenatal Genetic Screening
A

Genetic study. After performing in vitro fertilization and before transfer to the uterus, the genetic material of the embryo is examined in order to detect likely genetic alterations. It is performed when the embryos are at 6-8 cell stage, generally on the 3rd day of development, or when they are at the blastocyst stage, usually on day 5 of development

B

Embryo biopsy. A biopsy is done on each one and those
with an abnormal number of chromosomes are discarded
C

Embryo transfer. From 1 to 3 healthy embryos are
transferred. The embryos that are not transferred can be frozen

PGS by array CGH is a laboratory technique that allows us to study the DNA of eggs or embryos in order to select those with a correct genetic load.
This technique is done as part of IVF programmes. Your doctor will tell you whether it could be helpful in your case.

The diagnosis can be obtained in two different ways:

  • Preimplantation Genetic Screening with embryos
    Once in vitro fertilization is performed and before transferring the embryo to the uterus, the genetic material is examined in order to detect whether the genetic load is correct.

    This study is performed when the embryos are at 6-8 cell stage, generally on the 3rd day of development. In order to examine their genetic material a biopsy is carried out on each embryo and only the healthy ones are selected for transfer to the uterus.

  • Preconception Diagnosis with eggs
    Genetic diagnosis to detect genetic disorders eggs or chromosomal egg before the embryo is formed.

    This technique analyses a specific part of the egg, the polar body, so it can only detect inherited diseases of maternal origin.

    In order to study the mature egg a polar body biopsy is carried out by making a small opening in the zona pellucida that surrounds it. Having identified the normal eggs, they are inseminated by Intracytoplasmic Sperm Injection (ICSI) thus obtaining embryos suitable for transfer to the uterus.

Last Updated: February, 2016
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