What is implantation failure?
Implantation failure is one of the most challenging situations for individuals undergoing fertility treatment. It refers to the absence of a clinical pregnancy after the transfer of good-quality embryos over several in vitro fertilization (IVF) cycles.
Although there is no universally agreed definition, recurrent implantation failure is generally considered to occur after at least three unsuccessful embryo transfers, provided that chromosomally normal embryos have been transferred and the uterus presents favorable conditions.
Most common causes of implantation failure
The causes of implantation failure can be multiple and often complex. They can be grouped into three main categories: embryonic, uterine and systemic.
- Embryonic causes include genetic abnormalities, especially in oocytes from women of advanced reproductive age, or issues in embryo development, which may also stem from poor sperm quality.
- Uterine causes include conditions such as submucosal fibroids, polyps, intrauterine adhesions, infections or inadequate endometrial receptivity.
- Finally, there are immunological, hematological or even lifestyle-related factors, such as smoking, chronic stress or being overweight, that can negatively impact implantation.
How is it diagnosed and treated?
To prevent and address this issue, Eugin offers a personalized and multidisciplinary approach. First, we carry out a thorough assessment that may include genetic testing (such as the couple’s karyotype), thrombophilia screening, and imaging studies to evaluate uterine anatomy. In selected cases, we also use PGT-A to analyze embryos for chromosomal abnormalities prior to transfer, advanced tools to assess the endometrium, or immunological testing.
The treatment of recurrent implantation failure must be tailored to each patient or couple, but may include lifestyle changes, modifications in the protocol for preparing the uterus for embryo transfer, uterine surgery when necessary, or in some cases, the use of specific adjuvant therapies (such as immunomodulators or intrauterine PRP infusions).
When to consider egg donation
When implantation failure is due to poor oocyte quality—especially in women over 40 or with low ovarian reserve—egg donation can be a highly effective option. Using eggs from a healthy donor under the age of 35 significantly increases the chances of obtaining viable embryos and, consequently, achieving implantation and pregnancy. This alternative is particularly relevant for women who have undergone several unsuccessful IVF cycles, even with seemingly normal embryos.
Each patient is unique, which is why our treatments are individually designed to optimize all factors involved in implantation. Beyond medical treatment, we also provide emotional support throughout the process, as the psychological impact of implantation failure can be significant.
In conclusion, although implantation failure represents a major challenge in reproductive medicine, we have advanced diagnostic and therapeutic tools to face it with hope, precision and compassion. Thanks to scientific progress and accumulated experience, finding a path to motherhood is more possible than ever—even after several failed attempts.
Have you experienced several failed implantation attempts?
At Eugin, we specialize in complex reproductive cases and offer you the support of a highly experienced medical team and cutting-edge technology. You can book a first consultation, or request a second medical opinion to assess your situation individually. We are here to help you find the best path to pregnancy, with the guidance and care you deserve.
